Answer to Controversy: miR-10a Replacement Approaches Do Not Offer Protection against Chemotherapy-Induced Gonadotoxicity in Mouse Model
نویسندگان
چکیده
منابع مشابه
GnRH agonist acts as ovarian protection in chemotherapy induced gonadotoxicity: an experiment using a rat model.
To reduce chemotherapy induced gonadotoxicity, co-treatment with gonadotropin releasing hormone against analogue (GnRHa) was tested using rat model. Leuprorelin acetate (Leuplin) with or without cisplatin (CDDP) was given subcutaneously at a dose of 9.4 microg/ml to Wistar strain female rats. The total number of follicles was counted and the maturation of follicles was evaluated at the largest ...
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Cisplatin had shown anti-leishmanial effect both in vitro and in vivo against murine visceral leishmaniasis. The present study was designed to evaluate the effect of cisplatin on gonads of Leishmania donovani infected BALB/c mice. In drug treated animals, mild reduced spermatogenesis was observed but when antioxidants were supplemented along with cisplatin, the morphological characteristics of ...
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Gillich et al. [1] report on an excellent transplant success rate of 77 kidney grafts performed over a 10-year period, using cadaver donor organs that were obtained and transplanted locally, without taking HLA matching into consideration. They hypothesize that the good result was due to the fact that the kidneys were not exposed to prolonged ischaemic preservation. Paired kidneys that were ship...
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ژورنال
عنوان ژورنال: International Journal of Molecular Sciences
سال: 2019
ISSN: 1422-0067
DOI: 10.3390/ijms20194958